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When validating SBML files from biomodels, we get the following warning whenever a species is annotated as messenger RNA:
- The value of the 'sboTerm' attribute on a <species> is expected to be an SBO identifier (http://www.biomodels.net/SBO/). In SBML Level 2 prior to Version 4 it is expected to refer to a participant physical type (i.e., terms derived from SBO:0000236, "participant physical type"); in Versions 4 and above it is expected to refer to a material entity (i.e., terms derived from SBO:0000240, "material entity").
Reference: L2V4 Section 5
SBO term 'SBO:0000278' on the <species> is not in the appropriate branch.
It's possible that this is a validation problem, but I do think that messenger RNA is indeed a material entity (as well as being a 'functional entity'), and should be cross-added to that branch (like 'gene' is).
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