As there's a ton of 0 values in the clouds, this might significantly cut down on the number of written values and thus making saves (faster and) smaller. Though overall disk effect is likely negligible as the raw data is compressed.
One complication is that the different clouds inside a single plane are all interleaved meaning the RLE is likely less effective than it could be. So to test this also the vec4's would likely need to be split up so that each x in a chunk is written at once, and then the y values etc.