We've been using (a variant of) the callback-free-itx extension with Prisma 4 in production for a while now, it's been rock solid. We're exploring the upgrade to Prisma 5 and finding that periodically we're getting "unable to start a transaction in the given time" P2028 errors. We've narrowed it down to the callback free interactive transaction code. If we don't use transactions at all then we're stable.
I swapped over our implementation to be the exact one in this repository and we're seeing the same behavior. I don't have a small reproduction case yet, I'm opening this ticket for visibility and in the hope that somebody else has seen this on Prisma 5 and perhaps can point me in the right direction.